Acitretin is a second-generation retinoid and a metabolite of etretinate. While effective for severe psoriasis, its physical properties are highly dependent on the crystallization process. Because different crystalline structures (polymorphs) can change the drug’s solubility and shelf-life, precise characterization is essential for regulatory compliance and patient safety ( ResearchGate ). 2. Characterization of Polymorphic Forms
: Form I can be quantitatively converted into Form II. 54757.rar
: Also features carboxylic dimers but is located on crystallographic inversion centers. Acitretin is a second-generation retinoid and a metabolite
: These findings suggest that the manufacturing environment (heat and solvent choice) directly determines which form of the drug is produced. 4. Conclusion 54757.rar