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Splenic lymphomas remain a diagnostic challenge due to their rarity and overlap with other indolent B-cell neoplasms. Advances in molecular profiling and the success of anti-CD20 monoclonal antibodies have shifted the treatment paradigm away from invasive surgery toward targeted medical therapy. Suggested Resources for PDF Download

Splenic lymphomas represent a heterogeneous group of rare B-cell neoplasms primarily involving the spleen, bone marrow, and often the peripheral blood. The most common subtype is Splenic Marginal Zone Lymphoma (SMZL). This paper reviews the clinical presentation, diagnostic criteria (histology and immunophenotype), and evolving therapeutic strategies for these malignancies. 1. Introduction Download Lymphomes splГ©niques pdf

Asymptomatic patients can often be monitored for years. Splenic lymphomas remain a diagnostic challenge due to

The World Health Organization (WHO) and the International Consensus Classification (ICC) categorize these into three main entities: The most common subtype is Splenic Marginal Zone

Splenic Lymphomas: Pathophysiological Characteristics, Diagnosis, and Management

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Peripheral blood smears often show "villous" lymphocytes (small cells with polar cytoplasmic projections). Immunophenotyping: Flow cytometry typically reveals