Are you running the or a digital release from Steam/GOG , as the installation paths for these fixes may vary slightly? Star Trek: Starfleet Command - PCGamingWiki
: If the game still fails to launch, try forcing a 640x480 resolution via the compatibility properties menu or using a tool like dgVoodoo to wrap older DirectX calls into modern versions . File: Star.Trek.Starfleet.Command.Gold.Edition....
The most critical piece of community advice for this game involves editing the configuration file to prevent immediate crashes upon starting a mission . Are you running the or a digital release