Involved in studies of membrane trafficking, including oocyte and mammalian cell patch-clamp experiments.
Soluble in water, commonly used at high concentrations (e.g., ≥75is greater than or equal to 75 5. Regulatory and Safety Storage Class: 11 (Combustible Solids).
Solutions are very unstable; they must be prepared immediately prior to use. g8634.mp4
Because the protein cannot break down the analog, the G-protein remains locked in its active, bound state. Activation Mechanism: It binds directly to G-protein -subunits. 3. Key Research Applications
While G-proteins hydrolyze GTP to GDP to turn "off" signaling, they cannot efficiently hydrolyze GTP- Solutions are very unstable; they must be prepared
-S) is a thiophosphate analog of guanosine triphosphate (GTP). The key difference is the substitution of a sulfur atom for an oxygen atom on the terminal phosphate group (γ-phosphate). G8634-1MG CAS Number: 94825-44-2 Formula: Molecular Weight: 562.98 Appearance: White to off-white powder Assay: 2. Biological Mechanism of Action The primary utility of GTP- -S lies in its resistance to hydrolysis by GTPases.
Technical Profile: Guanosine 5′-[γ-thio]triphosphate (GTP- -S) - G8634 1. Introduction and Chemical Nature Guanosine 5′-[γ-thio]triphosphate (GTP- Solutions are very unstable
Requires a dust mask (N95), eyeshields, and gloves. WGK: 3. Source References: Sigma-Aldrich Product Detail PubMed - Cell Signaling Studies Sigma-Aldrich SDS