The narrative jumps through time, connecting several distinct groups of characters:

: While Marsellus is out of town, Vincent is assigned to "entertain" Marsellus' wife, Mia Wallace (Uma Thurman). Their evening at Jackrabbit Slim’s includes a famous dance contest but takes a dark turn when Mia accidentally overdoses on heroin.

: Jules Winnfield (Samuel L. Jackson) and Vincent Vega (John Travolta) are two hitmen tasked with retrieving a mysterious glowing briefcase for their mob boss, Marsellus Wallace. Their journey involves philosophical debates about Royale with Cheese and a divine intervention that changes Jules' life.