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: Helen and Max track the infection's movement through the Emergency Department.
: Floyd learns that Lyn Malvo is pregnant, adding a new layer of complexity to their relationship.
As Dr. Max Goodwin and Dr. Helen Sharpe prepare to leave for London to start a new life together, they find themselves pulled back into the hospital one last time. Their departure is halted when a —a rare bacterial infection—rapidly spreads through New Amsterdam, leading to nine simultaneous "Code Blues" and multiple patient deaths. The Search for a Source The medical team races to find the origin of the outbreak:
The episode concludes with Max and Helen finally making the choice to leave for London, marking a major turning point for the series.
Standard treatments and modern antibiotics prove ineffective against the antibiotic-resistant strain. Facing a growing death toll, Max proposes a risky solution using , a drug from the 1950s that was pulled from the market because it causes severe kidney failure. To save the patients, the team decides to administer the drug while simultaneously placing every patient on dialysis to mitigate the damage. Dr. Walsh volunteers to be the first test subject; he survives, proving the treatment works. Emotional Subplots
: Dr. Mark Walsh, a recurring and beloved character, becomes infected and falls into critical condition, making the search for a cure deeply personal for the team. The Unorthodox Solution