Sloppy May 2026

(Transtrum et al., 2015): A definitive review describing the information theoretic framework based on the Fisher Information Matrix (FIM).

: The set of all possible model predictions forms a "manifold" that is often extremely narrow in some dimensions, resembling a "hyper-ribbon". Other Contexts of "Sloppy" in Research sloppy

: A few parameter combinations ("stiff") tightly constrain model behavior, while others ("sloppy") can vary by orders of magnitude without changing the output. (Transtrum et al