This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs.
The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions tm,cc,jp
The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane. This guide focuses on the molecular mechanism of
Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. ions are bound per domain, with specific significance
ions are bound per domain, with specific significance for the .
Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power
Structure and function of otoferlin, a synaptic protein of ... - PMC