Utilizes a deformable mirror to correct for system-level nonlinearities and optical aberrations, enabling sharp imaging across the entire 50 mm² area.
The system described in the 2026 publications (often referred to as the ULTRA system) provides an unprecedented combination of field-of-view (FOV) and depth. Multi-scale in vivo neuronal imaging. VAM_GS.Qiao.2.var
It allows researchers to visualize brain structures spanning from superficial layers down to 900 μm depth in a single study. Utilizes a deformable mirror to correct for system-level
Optimized for in vivo studies, involving anaesthetized animals to maintain consistency. It allows researchers to visualize brain structures spanning
The system sequences through Zernike modes to compensate for aberrations, with optimization processes sometimes completing in minutes, tailored for high-speed scanning (e.g., 133 Hz for ROI).
Employs advanced scanning techniques to achieve a total imaged volume of over 45 mm³. 3. Key Applications in Neuroscience